In the coming decades, the international community will face the challenges of reining in global climate change, ensuring food security for a growing population, and promoting sustainable development. Meeting these multiple challenges requires changes in the agricultural sector. Farmer-driven adaptation in Kenya and elsewhere in East Africa must include sustainable agricultural management practices. Many of these management practices also directly contribute to reducing greenhouse gas (GHG) emissions and increasing agricultural productivity and net revenues. This note is based on a report on the synergies and tradeoffs of agricultural management strategies used by farmers in seven districts in Kenya, spanning the country’s arid, semi-arid, temperate, and humid agroecological zones (AEZs). The note identifies win–win–win strategies among agricultural adaptation, mitigation, and profitability based on analyses using household survey data and crop and livestock simulation modeling.